Identification of a Novel Subset of Myeloid-Derived Suppressor Cells During Chronic Staphylococcal Infection That Resembles Immature Eosinophils. (23rd September 2017)

• Record Type: Journal Article
• Authors: Goldmann, Oliver; Beineke, Andreas; Medina, Eva
• Is Part Of: Journal of infectious diseases. Volume 216:Number 11(2017:Dec. 01)
• Page Start: 1444
• Page End: 1451
• Publication Date: 2017-09-23
• Subjects: myeloid-derived suppressor cells -- Staphylococcus aureus -- immunosuppression -- eosinophils -- chronic infection; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jix494
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract : In this study, we have identified a novel subset of immunoregulatory myeloid-derived suppressor cells during chronic Staphylococcus aureus infection that exhibit an immature eosinophil-like phenotype and exert a potent inhibitory effect on protective T-cell responses, thereby fostering bacterial persistence. Abstract: We have previously reported that myeloid-derived suppressor cells (MDSC), which are a heterogeneous population of immunosuppressive immature myeloid cells, expanded during chronic Staphylococcus aureus infection and promoted bacterial persistence by inhibiting effector T cells. Two major MDSC subsets, including monocytic MDSC and granulocytic MDSC, have been described to date. Here, we identified a new subset of MDSC (Eo-MDSC) in S. aureus -infected mice that phenotypically resembles eosinophils. Eo-MDSC exhibit eosinophilic cytoplasmic granules and express CD11b, the eosinophil marker Syglec-F, variable levels of CCR3, and low levels of interleukin-5Rα. Furthermore, Eo-MDSC accumulated at the site of infection and exerted a potent immunosuppressive effect on T-cell responses that was mediated by nitric oxide-dependent depletion of l -arginine. Increases in the number of Eo-MDSC by adoptive transfer caused a significant exacerbation of infection in S. aureus -infected mice. This study sheds new light on the heterogeneity and complexity of MDSC during chronic infection.