Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics. Issue 1 (1st January 2015)

• Record Type: Journal Article
• Authors: Chen, J.; Kwong, D. L.; Cao, T.; Hu, Q.; Zhang, L.; Ming, X.; Chen, J.; Fu, L.; Guan, X.
• Is Part Of: Diseases of the esophagus. Volume 28:Issue 1(2015)
• Page Start: 84
• Page End: 89
• Publication Date: 2015-01-01
• Subjects: esophageal cancer -- MicroRNA -- proteomics -- transcriptomics; Esophagus -- Diseases -- Periodicals; 616.32
• DOI: 10.1111/dote.12088
• Languages: English
• ISSNs: 1120-8694

Abstract

Summary: Esophageal cancer is aggressive and has poor prognosis. Esophageal squamous cell carcinoma (ESCC) is histologically the most prevalent type of esophageal cancer and ranked as the sixth leading cause of cancer death worldwide. In recent years, cancer has been widely regarded as genetic disease, as well as epigenetic abnormalities including DNA methylation, histone deacetylation, chromatin remodeling, gene imprinting and noncoding RNA regulation. In this review, we will provide a general overview of genes, proteins and microRNAs that are involved in the development of ESCC, which aims to enhance our understanding of molecular mechanisms implicated in ESCC development and progression.