Immunomodulatory effects of Echinacea and Pelargonium on the innate and adoptive immunity in calves. Issue 1 (1st January 2018)

• Record Type: Journal Article
• Authors: Seckin, Cuneyt; Alpun Kalayci, Gamze; Turan, Nuri; Yilmaz, Aysun; Cizmecigil, Utku Y.; Aydin, Ozge; Richt, Juergen A.; Yilmaz, Huseyin
• Is Part Of: Food and agricultural immunology. Volume 29:Issue 1(2018)
• Page Start: 744
• Page End: 761
• Publication Date: 2018-01-01
• Subjects: Calf -- immunity -- cytokine -- IgG -- γ-interferon -- PCR -- Echinacea -- Pelargonium; Immunochemistry -- Periodicals; Food -- Analysis -- Periodicals; Immunoassay -- Periodicals; 616.079
• DOI: 10.1080/09540105.2018.1444738
• Languages: English
• ISSNs: 0954-0105

Abstract

ABSTRACT: Immunomodulatory effects of Echinacea purpurae and Pelargonium sidoides in calves were investigated. Sixty 25-day-old nonvaccinated calves living in integrated farm unit were randomly selected and were divided into 5 treatment groups consisting of 12 calves each; 4 groups were receiving different amounts and/or times of Echinacea and Pelargonium and the control group received placebo. Blood levels of γ-interferon, cytokine gene expression, lactoferrin and total IgG were analysed on days 0, 9, and 30. When levels for total IgG, γ-interferon, mRNAs for the γ-interferon, IL-1-β, IL-4 and the tumour necrosis factor-α genes were compared from days 0 to 9 post-treatment, significant differences were found between treated and non-treated calves using various amounts of Echinacea and Pelargonium ; a doses of 250 mg Echinacea and 62.5 mg Pelargonium for 5 days seems to be ideal. Echinacea purpurae and Pelargonium sidoides are able to modulate immune functions in calves.