The Stability and Influence of Barriers to Medication Adherence on Seizure Outcomes and Adherence in Children With Epilepsy Over 2 Years. (22nd June 2017)

• Record Type: Journal Article
• Authors: Ramsey, Rachelle R; Zhang, Nanhua; Modi, Avani C
• Is Part Of: Journal of pediatric psychology. Volume 43:Number 2(2018)
• Page Start: 122
• Page End: 132
• Publication Date: 2017-06-22
• Subjects: barriers -- epilepsy -- medication adherence -- pediatric; Clinical child psychology -- Periodicals; 618.9289005
• DOI: 10.1093/jpepsy/jsx090
• Languages: English
• ISSNs: 0146-8693

Abstract

Abstract: Objective: To determine the stability and influence of adherence barriers on medication adherence and seizure control in pediatric epilepsy. Methods: Caregivers of 118 children aged 2–12 years old with epilepsy completed the Pediatric Epilepsy Medication Self-Management Questionnaire at nine time points over 2 years post diagnosis. Electronically monitored antiepileptic drug adherence and seizure outcome data were collected. Results: Hierarchical linear modeling results for overall barriers remained stable over 2 years. Specific item-level barriers were also generally stable over time, with the exception of running out of medication becoming more of a barrier over time. No specific barriers were related to seizure control; however, difficulties swallowing medication, forgetting, and medication refusal were related to electronically monitored adherence over time. Conclusions: Assessing for specific adherence barriers over time may lead to identification of interventions that result in improved adherence and care.