Cyclophilin A and EMMPRIN (CD147) in cardiovascular diseases. (11th February 2014)

• Record Type: Journal Article
• Authors: Seizer, Peter; Gawaz, Meinrad; May, Andreas E.
• Is Part Of: Cardiovascular research. Volume 102:Number 1(2014)
• Page Start: 17
• Page End: 23
• Publication Date: 2014-02-11
• Subjects: EMMPRIN -- Cyclophilin A -- Inflammation; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Periodicals; 616.1
• DOI: 10.1093/cvr/cvu035
• Languages: English
• ISSNs: 0008-6363

Abstract

Abstract: Cyclophilin A (CyPA) is an abundantly expressed intracellular protein. It exerts a variety of functions due to its peptidyl–prolyl cis – trans isomerase (PPIase) activity. When released into the extracellular space, CyPA binds to its extracellular receptor CD147 (EMMPRIN) and thereby initiates a cascade of inflammatory processes. Recent data indicate that both extra- and intracellular CyPA significantly contribute to cardiovascular inflammation, myocardial ischaemia and reperfusion injury, and myocardial remodelling processes. Thus, CyPA appears to represent a novel target to treat vascular and myocardial inflammation.