RNA editing in mesothelioma: a look forward. Issue 10 (14th October 2020)

• Record Type: Journal Article
• Authors: Hariharan, Ananya; Sun, Suna; Wipplinger, Martin; Felley-Bosco, Emanuela
• Is Part Of: Open biology. Volume 10:Issue 10(2020)
• Publication Date: 2020-10-14
• Subjects: mesothelioma -- RNA editing -- adenosine deaminase acting on double-stranded RNA -- type 1 interferon signalling; Biology -- Periodicals; 570
• DOI: 10.1098/rsob.200112
• Languages: English
• ISSNs: 2046-2441

Abstract

Abstract : Abstract : RNA editing is a post-transcriptional process increasing transcript diversity, thereby regulating different biological processes. We recently observed that mutations resulting from RNA editing due to hydrolytic deamination of adenosine increase during the development of mesothelioma, a rare cancer linked to chronic exposure to asbestos. This review gathers information from the published literature and public data mining to explore several aspects of RNA editing and their possible implications for cancer growth and therapy. We address possible links between RNA editing and particular types of mesothelioma genetic and epigenetic alterations and discuss the relevance of an edited substrate in the context of current chemotherapy or immunotherapy.