Association Between Baseline Uric Acid and the Risk of Acute Pancreatitis: A Prospective Cohort Study. Issue 8 (September 2022)

• Record Type: Journal Article
• Authors: Su, Afang; Yuan, Xiaojie; Zhu, Guoling; Jiang, Xiaozhong; Shu, Rong; Yang, Wenhao; Wu, Shouling; Chen, Shuohua; Wang, Li; Cui, Liufu
• Is Part Of: Pancreas. Volume 51:Issue 8(2022)
• Page Start: 966
• Page End: 971
• Publication Date: 2022-09
• Subjects: acute pancreatitis -- uric acid -- heavy drinkers -- cohort -- AP - acute pancreatitis -- CI - confidence interval -- HR - hazard ratio -- TG - triglycerides -- UA - uric acid; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000002137
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Objectives: The aim of the study is explore the association between serum uric acid (UA) and acute pancreatitis (AP) risk in a Chinese population. Methods: We included 124, 316 participants who enrolled in the Kailuan cohort from 2006 to 2009. We fitted Cox models to estimate the correlation between UA and AP. Result: During an average follow-up of 11.97 years (standard deviation, 2.16 years), 396 AP developed. The incidence rates from quartile 1 to quartile 4 of AP were 20.76, 18.78, 30.58, and 36.79 per 100, 000 person-years, respectively. Multivariate analysis showed a significantly increased risk in quartile 3 (hazard ratio [HR], 1.42; 95% confidence interval [CI], 1.05–1.91) and quartile 4 (HR, 1.61; 95% CI, 1.19–2.17) compared with quartile 1. The association may be modified by alcohol use ( P for interaction = 0.017). The quartile 4 group with excessive alcohol consumption showed an enormously increased risk of AP (HR, 9.09; 95% CI, 1.18–70.21) than those without (HR, 1.46; 95% CI, 1.07–2.00). Conclusions: Elevated serum UA is an independent risk factor for AP. Surveillance of serum UA, especially among heavy drinkers, may be helpful for AP prevention.