Changed firing activity of nigra dopaminergic neurons in Parkinson's disease. (January 2023)

• Record Type: Journal Article
• Authors: Chen, Xin-Yi; Liu, Cui; Xue, Yan; Chen, Lei
• Is Part Of: Neurochemistry international. Volume 162(2023)
• Publication Date: 2023-01
• Subjects: Firing activity -- Dopaminergic neurons -- Substantia nigra pars compacta -- Parkinson's disease; Neurochemistry -- Periodicals; Neurochemistry -- Periodicals; Neurochimie -- Périodiques; Neurochemistry; Periodicals; 612.804205
• DOI: 10.1016/j.neuint.2022.105465
• Languages: English
• ISSNs: 0197-0186

Abstract

Abstract: Parkinson's disease is the second most common neurodegenerative disease which is characterized by selective degeneration of dopaminergic neurons in the substantia nigra pars compacta. The intrinsic neuronal firing activity is critical for the functional organization of brain and the specific deficits of neuronal firing activity may be associated with different brain disorders. It is known that the surviving nigra dopaminergic neurons exhibit altered firing activity, such as decreased spontaneous firing frequency, reduced number of firing neurons and increased burst firing in Parkinson's disease. Several ionic mechanisms are involved in changed firing activity of dopaminergic neurons under parkinsonian state. In this review, we summarize the changes of spontaneous firing activity as well as the possible mechanisms of nigra dopaminergic neurons in Parkinson's disease. This review may let us clearly understand the involvement of neuronal firing activity of nigra dopaminergic neurons in Parkinson's disease. Highlights: Firing property of dopaminergic neurons is associated with manifestation of PD. The surviving dopaminergic neurons exhibit altered firing activity in PD. Different ionic mechanisms are involved in the changes of firing activity.