COVID‐associated non‐vasculitic thrombotic retiform purpura of the face and extremities: A case report. Issue 12 (27th December 2022)

• Record Type: Journal Article
• Authors: Bunch, Connor M.; Zackariya, Nuha; Thomas, Anthony V.; Langford, Jack H.; Aboukhaled, Michael; Thomas, Samuel J.; Ansari, Aida; Patel, Shivani S.; Buckner, Hallie; Miller, Joseph B.; Annis, Christy L.; Quate‐Operacz, Margaret A.; Schmitz, Leslie A.; Pulvirenti, Joseph J.; Konopinski, Jonathan C.; Kelley, Kathleen M.; Hassna, Samer; Nelligan, Luke G.; Walsh, Mark M.
• Is Part Of: Clinical case reports. Volume 10:Issue 12(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-27
• Subjects: acral lesions -- chilblains -- COVID‐19 -- exanthema -- purpura -- SARS‐CoV‐2 -- vasculitis; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.6790
• Languages: English
• ISSNs: 2050-0904

Abstract

Abstract: SARS‐CoV‐2 infection can manifest many rashes. However, thrombotic retiform purpura rarely occurs during COVID‐19 illness. Aggressive anti‐COVID‐19 therapy with a high‐dose steroid regimen led to rapid recovery. This immunothrombotic phenomenon likely represents a poor type 1 interferon response and complement activation on the endothelial surface in response to acute infection. Abstract : COVID‐associated rashes in adults usually associate with more severe COVID‐19 illness. For older, comorbid patients with mild to moderate COVID‐19 illness who develop a rash, administer early immunomodulating therapy to mitigate disease progression.