Gestational growth trajectories derived from a dynamic fetal–placental scaling law. Issue 159 (31st October 2019)

• Record Type: Journal Article
• Authors: Baller, Daniel; Thomas, Diana M.; Cummiskey, Kevin; Bredlau, Carl; Schwartz, Nadav; Orzechowski, Kelly; Miller, Richard C.; Odibo, Anthony; Shah, Ruchit; Salafia, Carolyn M.
• Is Part Of: Journal of the Royal Society interface. Volume 16:Issue 159(2019)
• Publication Date: 2019-10-31
• Subjects: placenta -- placental volume -- differential equation -- logistic growth model -- fetal growth curves -- nonlinear regression; Physical sciences -- Research -- Periodicals; Life sciences -- Research -- Periodicals; Interdisciplinary research -- Periodicals; 570.5
• DOI: 10.1098/rsif.2019.0417
• Languages: English
• ISSNs: 1742-5689

Abstract

Abstract : Fetal trajectories characterizing growth rates in utero have relied primarily on goodness of fit rather than mechanistic properties exhibited in utero . Here, we use a validated fetal–placental allometric scaling law and a first principles differential equations model of placental volume growth to generate biologically meaningful fetal–placental growth curves. The growth curves form the foundation for understanding healthy versus at-risk fetal growth and for identifying the timing of key events in utero .