Clinical Features of 69 Cases With Coronavirus Disease 2019 in Wuhan, China. (16th March 2020)

• Record Type: Journal Article
• Authors: Wang, Zhongliang; Yang, Bohan; Li, Qianwen; Wen, Lu; Zhang, Ruiguang
• Is Part Of: Clinical infectious diseases. Volume 71:Number 15(2020)
• Page Start: 769
• Page End: 777
• Publication Date: 2020-03-16
• Subjects: coronavirus -- pneumonia -- Wuhan; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa272
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Background: From December 2019 to February 2020, 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a serious outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China. Related clinical features are needed. Methods: We reviewed 69 patients who were hospitalized in Union hospital in Wuhan between 16 January and 29 January 2020. All patients were confirmed to be infected with SARS-CoV-2, and the final date of follow-up was 4 February 2020. Results: The median age of 69 enrolled patients was 42.0 years (interquartile range 35.0–62.0), and 32 patients (46%) were men. The most common symptoms were fever (60 [87%]), cough (38 [55%]), and fatigue (29 [42%]). Most patients received antiviral therapy (66 [98.5%] of 67 patients) and antibiotic therapy (66 [98.5%] of 67 patients). As of 4 February 2020, 18 (26.9%) of 67 patients had been discharged, and 5 patients had died, with a mortality rate of 7.5%. According to the lowest SpO2 during admission, cases were divided into the SpO2 ≥ 90% group (n = 55) and the SpO2 < 90% group (n = 14). All 5 deaths occurred in the SpO2 < 90% group. Compared with SpO2 ≥ 90% group, patients of the SpO2 < 90% group were older and showed more comorbidities and higher plasma levels of interleukin (IL) 6, IL10, lactate dehydrogenase, and C reactive protein. Arbidol treatment showed tendency to improve the discharging rate and decrease the mortality rate. Conclusions: COVID-19 appears to show frequent fever, dry cough, and increase of inflammatory cytokines, and induced a mortality rate of 7.5%. Older patients or those with underlying comorbidities are at higher risk of death. Abstract : In this retrospective case series that included 69 adults in Wuhan, 29% of patients showed dyspnea and 20% of cases showed SpO2 < 90%. Patients with SpO2 < 90% had a significantly higher risk of death. Abidol showed initial therapeutic effect.