Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19). (2nd December 2020)

• Record Type: Journal Article
• Authors: Anderson, Elizabeth M; Diorio, Caroline; Goodwin, Eileen C; McNerney, Kevin O; Weirick, Madison E; Gouma, Sigrid; Bolton, Marcus J; Arevalo, Claudia P; Chase, Julie; Hicks, Philip; Manzoni, Tomaz B; Baxter, Amy E; Andrea, Kurt P; Burudpakdee, Chakkapong; Lee, Jessica H; Vella, Laura A; Henrickson, Sarah E; Harris, Rebecca M; Wherry, E John; Bates, Paul; Bassiri, Hamid; Behrens, Edward M; Teachey, David T; Hensley, Scott E
• Is Part Of: Journal of the Pediatric Infectious Diseases Society. Volume 10:Number 5(2021)
• Page Start: 669
• Page End: 673
• Publication Date: 2020-12-02
• Subjects: antibodies -- COVID-19 -- multisystem inflammatory syndrome in children (MIS-C) -- pediatric -- SARS-COV-2; Communicable diseases in children -- Periodicals; Children -- Diseases -- Periodicals; 618.929
• DOI: 10.1093/jpids/piaa161
• Languages: English
• ISSNs: 2048-7193

Abstract

Abstract: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike immunoglobulin G (IgG) titers compared with those with severe coronavirus disease 2019, likely reflecting a longer time since the onset of infection in MIS-C patients.