Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis. (17th September 2020)

• Record Type: Journal Article
• Authors: Leslie, Jhansi L; Weddle, Erin; Yum, Lauren K; Lin, Ye; Jenior, Matthew L; Lee, Benjamin; Ma, Jennie Z; Kirkpatrick, Beth D; Nayak, Uma; Platts-Mills, James A; Agaisse, Herve F; Haque, Rashidul; Petri, William A
• Is Part Of: Clinical infectious diseases. Volume 72:Number 11(2021)
• Page Start: e868
• Page End: e871
• Publication Date: 2020-09-17
• Subjects: blood-group antigens -- Lewis antigens -- shigellosis; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa1409
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.