Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2. (18th December 2020)

• Record Type: Journal Article
• Authors: Parsons, Emily; Timlin, Matthew; Starr, Clarise; Fries, Anthony; Wells, Ronald; Studer, Matthew; Sainato, Rebecca
• Is Part Of: Journal of the Pediatric Infectious Diseases Society. Volume 10:Number 5(2021)
• Page Start: 695
• Page End: 697
• Publication Date: 2020-12-18
• Subjects: COVID-19 -- D614G -- MIS-C -- pseudotumor cerebri syndrome -- SARS-CoV-2 -- viral lineage; Communicable diseases in children -- Periodicals; Children -- Diseases -- Periodicals; 618.929
• DOI: 10.1093/jpids/piaa167
• Languages: English
• ISSNs: 2048-7193

Abstract

Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe to be the earliest case of MIS-C, occurring in February 2020. Our patient's SARS-CoV-2 infection was caused by an emerging lineage with the D614G variant in the spike protein. This lineage would subsequently become the predominant cause of SARS-CoV-2 outbreaks in Europe and the United States where MIS-C was first described.