Deep Brain Stimulation in Epilepsy: A Role for Modulation of the Mammillothalamic Tract in Seizure Control?. Issue 3 (18th May 2020)

• Record Type: Journal Article
• Authors: Schaper, Frédéric L W V J; Plantinga, Birgit R; Colon, Albert J; Wagner, G Louis; Boon, Paul; Blom, Nadia; Gommer, Erik D; Hoogland, Govert; Ackermans, Linda; Rouhl, Rob P W; Temel, Yasin
• Is Part Of: Neurosurgery. Volume 87:Issue 3(2020)
• Page Start: 602
• Page End: 610
• Publication Date: 2020-05-18
• Subjects: Neuromodulation -- DRE -- Drug-resistant epilepsy -- Thalamus -- Mammillothalamic tract -- White matter stimulation; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyaa141
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: BACKGROUND: Deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) can improve seizure control for patients with drug-resistant epilepsy (DRE). Yet, one cannot overlook the high discrepancy in efficacy among patients, possibly resulting from differences in stimulation site. OBJECTIVE: To test the hypothesis that stimulation at the junction of the ANT and mammillothalamic tract (ANT-MTT junction) increases seizure control. METHODS: The relationship between seizure control and the location of the active contacts to the ANT-MTT junction was investigated in 20 patients treated with ANT-DBS for DRE. Coordinates and Euclidean distance of the active contacts relative to the ANT-MTT junction were calculated and related to seizure control. Stimulation sites were mapped by modelling the volume of tissue activation (VTA) and generating stimulation heat maps. RESULTS: After 1 yr of stimulation, patients had a median 46% reduction in total seizure frequency, 50% were responders, and 20% of patients were seizure-free. The Euclidean distance of the active contacts to the ANT-MTT junction correlates to change in seizure frequency ( r 2 = 0.24, P = .01) and is ∼30% smaller ( P = .015) in responders than in non-responders. VTA models and stimulation heat maps indicate a hot-spot at the ANT-MTT junction for responders, whereas non-responders had no evident hot-spot. CONCLUSION: Stimulation at the ANT-MTT junction correlates to increased seizure control. Our findings suggest a relationship between the stimulation site and therapy response in ANT-DBS for epilepsy with a potential role for the MTT. DBS directed at white matter merits further exploration for the treatment of epilepsy. Graphical Abstract: