Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response. (9th October 2020)

• Record Type: Journal Article
• Authors: Murugesan, Kanagavel; Jagannathan, Prasanna; Pham, Tho D; Pandey, Suchitra; Bonilla, Hector F; Jacobson, Karen; Parsonnet, Julie; Andrews, Jason R; Weiskopf, Daniela; Sette, Alessandro; Pinsky, Benjamin A; Singh, Upinder; Banaei, Niaz
• Is Part Of: Clinical infectious diseases. Volume 73:Number 9(2021)
• Page Start: e3130
• Page End: e3132
• Publication Date: 2020-10-09
• Subjects: interferon-γ release assay -- SARS-CoV-2 -- T cells -- IGRA -- immune response; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa1537
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: We investigated feasibility and accuracy of an interferon-γ release assay (IGRA) for detection of T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whole blood IGRA accurately distinguished between convalescent and uninfected healthy blood donors with a predominantly CD4 + T-cell response. SARS-CoV-2 IGRA may serve as a useful diagnostic tool in managing the coronavirus disease 2019 pandemic.