Assessment of the Hemophagocytic Lymphohistiocytosis HScore in Patients With Coronavirus Disease 2019. (28th September 2020)

• Record Type: Journal Article
• Authors: Clark, Kristina E N; Nevin, William D; Mahungu, Tabitha; Lachmann, Helen; Singh, Animesh
• Is Part Of: Clinical infectious diseases. Volume 73:Number 9(2021)
• Page Start: e3110
• Page End: e3112
• Publication Date: 2020-09-28
• Subjects: HLH -- COVID-19 -- HScore -- cytokine storm; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa1463
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: The clinical manifestation of moderate to severe coronavirus disease 2019 (COVID-19) has parallels to secondary hemophagocytic lymphohistiocytosis (HLH) both clinically and based on molecular inflammatory response. We found no evidence to support the utility of risk-stratifying COVID-19 patients using risk scoring methodology designed for HLH.