An algorithm to personalise the diagnosis of recurrent implantation failure based on theoretical cumulative implantation rate. Issue 6 (27th April 2021)

• Record Type: Journal Article
• Authors: Rozen, Genia; Rogers, Peter; Teh, Wan Tinn; Stern, Catharyn J; Polyakov, Alex
• Is Part Of: Human reproduction. Volume 36:Issue 6(2021)
• Page Start: 1463
• Page End: 1468
• Publication Date: 2021-04-27
• Subjects: infertility -- implantation -- assisted reproduction -- pregnancy -- endometrium -- recurrent implantation failure; Human reproduction -- Periodicals; 618
• DOI: 10.1093/humrep/deab091
• Languages: English
• ISSNs: 0268-1161

Abstract

Abstract: Recurrent implantation failure (RIF) is an imprecisely defined disorder lacking a robust scientific basis. The incomplete understanding of RIF provides significant diagnostic and therapeutic challenges, and a better understanding of the underlying issues is necessary to improve outcomes. We propose a novel concept termed 'Theoretical Cumulative Implantation Rate', the calculation of which is based on objective data, to define whether a patient should be diagnosed with RIF. An updated definition to assist with patient counselling and planning research studies, which is more precise and standardised, is well overdue.