Crystalglobulinemia: A Rare Presenting Manifestation of Multiple Myeloma. (September 2021)

• Record Type: Journal Article
• Authors: El Enany, Galal; Nagui, Noha; Nada, Hanan; Abdelkader, Heba A.; Sany, Iman; Nada, Ahmed; Mostafa, Mona; El-Ghanam, Omar; Abdel-Halim, Mona R. E.
• Is Part Of: American journal of dermatopathology. Volume 43:Number 9(2021)
• Publication Date: 2021-09
• Subjects: skin ulceration -- vascular thrombosis -- crystals -- crystalglobulinemia -- multiple myeloma -- hematological malignancy; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000001919
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract : Abstract: Crystalglobulinemia (CG) is a rare disorder characterized by crystallization of monoclonal immunoglobulins in the microcirculation leading to multiorgan vascular thrombosis and ischemic injury. The main cause of CG is multiple myeloma. We report a case of a 52-year-old man who presented with widespread necrotizing plaques and ulcerations. A skin biopsy revealed eosinophilic rectangular-shaped crystals occluding the lumina of blood vessels with no associated features of vasculitis. The crystals were Periodic acid-Schiff stain positive. The findings were diagnostic of CG. Extensive work up lead to the discovery of multiple myeloma. Awareness of CG is important because it may be the first presenting manifestation of an underlying serious hematological malignancy.