New-Onset of Inflammatory Bowel Disease in a Patient Treated With Teprotumumab for Thyroid Associated Ophthalmopathy. Issue 5 (September 2021)

• Record Type: Journal Article
• Authors: Ashraf, Davin C.; Jankovic, Ivana; El-Nachef, Najwa; Winn, Bryan J.; Kim, Grace E.; Kersten, Robert C.
• Is Part Of: Ophthalmic plastic and reconstructive surgery. Volume 37:Issue 5(2021)
• Publication Date: 2021-09
• Subjects: Eye -- Surgery -- Periodicals; Ophthalmic plastic surgery -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Ophthalmologic Surgical Procedures -- Periodicals; Ophthalmology -- Periodicals; Surgery -- Periodicals; 617.70592
• DOI: 10.1097/IOP.0000000000001943
• Languages: English
• ISSNs: 0740-9303

Abstract

Abstract : A patient with thyroid-associated ophthalmopathy was treated with teprotumumab and developed symptoms concerning for inflammatory bowel disease after her sixth infusion. Colonoscopy was performed, and mucosal biopsies identified evidence of active colitis consistent with a diagnosis of ulcerative colitis. Despite treatment with budesonide and mesalamine, the patient continued to be symptomatic one and a half months after cessation of teprotumumab and required infliximab to achieve good control of her inflammatory bowel disease. This case represents the first report of new-onset inflammatory bowel disease arising during treatment with teprotumumab. Abstract : This report describes the new-onset of inflammatory bowel disease in a patient receiving teprotumumab therapy for thyroid-associated ophthalmopathy.