Bone Marrow Activation After Chemotherapy Presenting as Diffuse Skeletal Uptake on 18F-Fluorocholine PET/CT. (October 2021)

• Record Type: Journal Article
• Authors: Taralli, Silvia; Cocciolillo, Fabrizio; Alitto, Anna Rita; Caldarella, Carmelo
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 10(2021)
• Publication Date: 2021-10
• Subjects: 18F-fluorocholine -- PET/CT -- bone marrow activation -- superscan -- chemotherapy -- prostate cancer; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003695
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Diffuse 18 F-FDG skeletal uptake due to chemotherapy-induced bone marrow activation is well documented, whereas it has never been reported with 18 F-fluorocholine. We described a patient with pelvic recurrence of prostate cancer at 18 F-fluorocholine PET/CT. A second PET/CT after docetaxel showed minimal residual activity in pelvis, but it revealed diffuse, intense 18 F-fluorocholine skeletal uptake. Considering biochemical and metabolic response and absence of morphologically suspected bone lesions, skeletal hyperactivity was interpreted as chemotherapy-related bone marrow rebound rather than diffuse metastatic involvement, as confirmed by its resolution after treatment ended. The occurrence of such 18 F-fluorocholine pattern should be considered to avoid imaging misinterpretation.