18F-Fluorothymidine PET for Functional Response Assessment Following Radiation Therapy for Extramedullary Hematopoiesis. (September 2021)

• Record Type: Journal Article
• Authors: Campbell, Belinda A.; Callahan, Jason; Cole-Sinclair, Merrole; MacManus, Michael; Hofman, Michael S.
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 9(2021)
• Publication Date: 2021-09
• Subjects: 18F-fluorothymidine PET -- 18F-FLT PET -- Chuvash polycythemia -- extramedullary hematopoiesis -- radiation therapy -- response assessment; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003566
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: As a marker of cellular proliferation, 18 F-fluorothymidine (FLT) PET can detect the distribution of proliferating hematopoiesis and has an emerging role in the investigation of hematopoietic disorders. These images demonstrate the novel utility of 18 F-FLT PET for imaging sites of extramedullary hematopoiesis (EMH) in a patient with Chuvash-type polycythemia and suggest a role for 18 F-FLT PET in response assessment following radiotherapy. Further, the discordant response observed in the irradiated marrow and sites of EMH is a unique discovery, possibly suggesting the influence of the microenvironment favoring more rapid recovery of proliferative function within EMH sites.