New therapies for esophageal strictures in children. Issue 5 (October 2021)

• Record Type: Journal Article
• Authors: Angelino, Giulia; Tambucci, Renato; Torroni, Filippo; De Angelis, Paola; Dall'Oglio, Luigi
• Is Part Of: Current opinion in pediatrics. Volume 33:Issue 5(2021)
• Publication Date: 2021-10
• Subjects: balloon and bougie dilators -- endoscopic incisional therapy -- esophageal stenting -- mytomicin C -- steroids; Pediatrics -- Periodicals; Pediatrics -- Periodicals -- Bibliography -- Periodicals; 618.92
• DOI: 10.1097/MOP.0000000000001049
• Languages: English
• ISSNs: 1040-8703

Abstract

Abstract : Purpose of review: The present review aims at describing recent advances in therapeutic strategies for the treatment of benign esophageal strictures in children. We discuss current knowledge and practice on esophageal dilations, which are still the mainstream of treatment. We present new evidence about adjuvant treatments for recurrent and refractory strictures, including endoscopic incisional therapy, esophageal stenting, intralesional or topical mytomicin C and intralesional, systemic or topical steroids. Recent findings: Current evidence on esophageal dilations is not sufficient to establish superiority of one of the available techniques, especially the use of balloon or bougie dilators, but a prospective international cohort study on anastomotic stricture in esophageal atresia is underway to address this issue. Recurrent and refractory strictures still represent a challenge, since none of the adjuvant pharmacological and mechanical interventions has shown to be enough feasible, effective and safe to revolutionize clinical practice. Summary: In the last couple of years, several encouraging results have been published on management of esophageal strictures in children. Further research is needed, hopefully directed toward secure, easily reproducible and minimally invasive measures.