Immunological studies of Morinda officinalis: How polysaccharides act as adjuvants. Issue 4 (4th May 2021)

• Record Type: Journal Article
• Authors: Feng, Haibo; Zhi, Hui; Hu, Xin; Yang, Yan; Zhang, Linzi; Liu, Qianqian; Feng, Yangyang; Wu, Daiyan; Yang, Xiaonong
• Is Part Of: Journal of carbohydrate chemistry. Volume 40:Issue 4(2021)
• Page Start: 156
• Page End: 178
• Publication Date: 2021-05-04
• Subjects: Adjuvant -- Morinda officinalis How polysaccharide -- rHBsAg; Carbohydrates -- Periodicals; 547.78
• DOI: 10.1080/07328303.2021.1954657
• Languages: English
• ISSNs: 0732-8303

Abstract

Abstract: Morinda officinalis polysaccharides (MOPS) were investigated for their physicochemical properties, monosaccharide composition, and immune-modulating effects in vitro and in vivo . In vitro, MOPS significantly promoted lymphocyte proliferation and increased IFN-γ and IL-4 secretion. In vivo, MOPS acted as adjuvant, which significantly up-regulated HBsAg-specific IgG and IgG isotype levels, promoted antigen-specific T cell proliferation and cytokine (IL-2 and IL-5) production, and induced CTL and NK cytotoxicity. Moreover, MOPS increased DC maturation. Overall, MOPS can serve as an adjuvant to promote humoral and cellular immune responses via promoting DC maturation, suggesting that MOPS may have potentials as a natural immune-enhancing agent. Graphical Abstract: UF0001