Three‐Dimensional Graphene Network Decorated with Bimetallic Cerium/Copper Oxide Nanoparticles for Non‐Enzymatic Diagnosis of Phenylketonuria. Issue 48 (21st December 2022)

• Record Type: Journal Article
• Authors: Rezaie, Maryam; Nemati, Fatemeh; Firoozbakhtian, Ali; Tabesh, Hadi; Ganjali, Mohammad Reza; Hosseini, Morteza
• Is Part Of: ChemistrySelect. Volume 7:Issue 48(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-21
• Subjects: 3D graphene composite electrochemical biosensor -- enzyme-free -- phenylketonuria; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202203123
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Exceptional sensitivity and user‐friendly operation of electrochemical sensors have made them a potential promise in diagnosing, monitoring, and treating Phenylketonuria (PKU). A three‐dimensional graphene matrix decorated with cerium and copper oxide particles was synthesized by a one‐pot hydrothermal technique. Because of several functional groups and active sites on the graphene composite, the fabricated sensor is able to detect PKU based on the non‐enzymatic sensing strategy. The bimetallic composite with excellent electrocatalyst activity accelerates the electrooxidation of phenylalanine. The as‐fabricated enzyme‐free sensor exhibited a wide linearity toward concentration of L‐phenylalanine (L‐Phe), from 50 to 8000 μm with R 2 =0.9935 and a detection limit of 12 μm (S/N=3). The experiments have been completed towards determining the L‐Phe concentrations in human serum with the recovery of 96 % and 105 %. Abstract : Here we synthesis a three‐dimensional graphene (3DGF) matrix decorated with cerium and copper oxide particles for an enzyme‐free detection of L‐phenylalanine (L‐Phe) in a linear range of 0.05‐8 mm and a detection limit as low as 12 μm .