Cytokine profile of macrophage activation syndrome associated with Kawasaki disease. (July 2019)

• Record Type: Journal Article
• Authors: Jinkawa, Asumi; Shimizu, Masaki; Nishida, Keigo; Kaneko, Shuya; Usami, Masaaki; Sakumura, Naoto; Irabu, Hitoshi; Takakuwa, Maiko; Inoue, Natsumi; Mizuta, Mao; Ikawa, Yasuhiro; Fujita, Shuhei; Yachie, Akihiro
• Is Part Of: Cytokine. Volume 119(2019)
• Page Start: 52
• Page End: 56
• Publication Date: 2019-07
• Subjects: Macrophage activation syndrome -- Kawasaki disease -- Soluble tumour necrosis factor receptor type II; MAS macrophage activation syndrome -- KD kawasaki disease -- IL interleukin -- sTNFR soluble tumour necrosis factor receptor -- IFN interferon -- TNF tumour necrosis factor -- CALs coronary artery lesions -- NK natural killer; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2019.03.001
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlights: IFN-γ and TNF-α are closely associated with the pathogenesis of MAS associated with KD. Serum sTNFR-II levels correlated positively with disease activity of MAS associated with KD. Serum sTNFR-II levels might be a useful marker to diagnose the transition to MAS. Abstract: The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I (sTNFR-I) and sTNFR-II levels were determined using enzyme-linked immunosorbent assay in 78 patients with KD, including five with MAS. Results were compared to the clinical features of MAS. Serum neopterin, IL-18, sTNFR-II levels and sTNFR-II/I ratio were significantly elevated in KD patients with MAS compared to those in the acute phase. Receiver operating characteristic curve analysis revealed areas under the curve and cutoff values of neopterin, IL-18, sTNFR-II levels and sTNFR-II/I ratio were 0.9750/30.0 nmol/L, 0.9813/1165 ng/mL, 0.9969/16, 600 pg/mL and 0.9875/4.475, respectively. Serum sTNFR-II levels correlated positively with disease activity. These findings indicate that overproduction of interferon (IFN)–γ and TNF-α reflected by increased serum levels of neopterin and sTNFR-II are closely associated with the pathogenesis of MAS associated with KD. Serum sTNFR-II levels might be a useful marker to diagnose the transition to MAS.