EP061/#647 Effect of the extent of radical excision on clinical outcomes after radical hysterectomy for early-stage cervical cancer: a meta-analysis. (4th December 2022)

• Record Type: Journal Article
• Authors: Hwang, Dong Won; Park, Min Young; Kim, Hee Seung; Kim, Jae-Weon; Park, Noh Hyun; Park, Soo Jin
• Is Part Of: International journal of gynecological cancer. Volume 32(2022)Supplement 3
• Page Start: A72
• Page End: A73
• Publication Date: 2022-12-04
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2022-igcs.152
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: Although the extended resection of the paracervix during radical hysterectomy causes an increase in surgical complications, there is no clear evidence of whether it can contribute to improved prognosis of cervical cancer. We performed a meta-analysis for investigating the association between the extent of radical excision and survival after radical hysterectomy for early-stage cervical cancer. Methods: We searched studies which compared disease-free survival (DFS) or overall survival (OS) between type I (A) or II (B) and type III (C) hysterectomy reported till January 2022. In total, we used six studies including 1, 010 patients with stage IB-IIB diseases in this meta-analysis. We compared DFS and OS, surgical outcomes, complications and the pattern of recurrence between the two groups. Results: There were no differences in DFS and OS (hazard ratios, 0.810 and 0.605; 95% confidence intervals [Cis], 0.539 to 1.215 and 0.324 to 1.130 between type I (A) or II (B) and type III (C) hysterectomy. Operation time and hospitalization were shorter, and blood loss and the rate of bladder dysfunction were less (standard difference in means, -1.213, -0.794, -1.010 and -0.855; 95% CIs, -1.360 to -1.065, -0.991 to -0.597, -1.170 to -0.850 and -1.233 to -0.558) in type I (A) or II (B) hysterectomy. However, there were no differences in surgical complications and the pattern of recurrence between the two groups. Conclusions: Type I (A) or II (B) hysterectomy may have the similar effect on survival to type III (C) hysterectomy for early-stage cervical cancer with an improvement of surgical outcomes and bladder dysfunction.