EP289/#608 Timing of recurrence and overall survival in epithelial ovarian cancer: a 10-year retrospective review in a teaching hospital. (4th December 2022)

• Record Type: Journal Article
• Authors: Okunade, Kehinde; Soibi-Harry, Adaiah; Ogunyemi, John; Thomas-Ogodo, Olufemi; Okoro, Austin; Osunwusi, Benedetto; Garba, Sunusi; Anorlu, Rose
• Is Part Of: International journal of gynecological cancer. Volume 32(2022)Supplement 3
• Page Start: A169
• Page End: A170
• Publication Date: 2022-12-04
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2022-igcs.380
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: The timing of recurrence of epithelial ovarian cancer (EOC) after a standard primary treatment is an important indicator of the degree of response of the tumour to treatment. It, however, remains unclear if the timing of recurrence will predict survival outcomes. Methods: Data was extracted from patients who underwent standard primary treatment and follow-up after EOC diagnosis between January 2011 and December 2020. Descriptive statistics were computed for all patients' data and Kaplan-Meier survival estimates and Cox proportional hazards model adjusted for covariates were used for analyses. Results: The risks of recurrence of EOC increased steadily with increasing time from the start of primary treatment from 13.6% in 6-months to 71.0% after 12-months. In the final multivariate analyses, recurrence within 6 months of treatment was a significant independent predictor of poor OS in EOC patients (HR=7.23, 95%CI: 3.87–13.51, P<0.01). Conclusions: Our study suggests that recurrence within 6-months is an important prognostic factor that predicts poor OS in EOC. Early tumour recurrence may be a useful surrogate of overall survival and thus this information should be considered in the design of future tailored randomized controlled trials. Future strategies to improve OS in EOC patients should focus on identifying effective measures to prevent early tumour recurrence.