EP038/#548 Predictive factors of axillary lymph node involvement in Tunisian women with early breast cancer. (4th December 2022)

• Record Type: Journal Article
• Authors: Achouri, Leila; Mansouri, Houyem; Jellali, Amani; Henchiri, Houda; Boukhris, Sabrine; Boujelbene, Nedia; Zemni, Ines
• Is Part Of: International journal of gynecological cancer. Volume 32(2022)Supplement 3
• Page Start: A63
• Page End: A64
• Publication Date: 2022-12-04
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2022-igcs.129
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: This study aimed to identify clinicopathological predictive factors of axillary lymph node metastases in patients with early breast cancer. Methods: We included patients with clinical T0, T1 andT2 invasive breast carcinoma who underwent resection of the primary tumor and axillary staging by sentinel lymph node biopsy and/or axillary lymph node dissection between 2012 and 2018 Results: Of the 135patients included, 41.5% had ALNI. Regarding univariate analysis, clinical factors correlated with positive ALNM were clinical tumour size>30 mm(p=0.006), clinical tumour stage(p=0.047), clinical number of tumours (p=0.016), clinical axillary nodal status(p<0.001) and nodal status on ultrasound (p<0.001). Pathologic factors associated with nodal involvement were pathologic tumour stage (p=0.003), tumor grade SBR(p=0.001), number of foci (p<0.001), lympho vascular invasion(p<0.001), perineural invasion(p=0.001) and Ki67>20%(p=0.049). In multivariate logistic regression, clinical axillary nodal status (OR=4.31, CI 2.26–50, p=0.032), pathologic tumour stage (OR=3.66, CI 2–19.23, p=0.016) and lympho vascular invasion(LVI) (OR=4.29, CI 1.91–29.41, p=0.026) remained as independant predictors of ALNI. Conclusions: Based on these results, we suggest that clinical axillary nodal status, pathologic tumor stage, and LVI are predictive factors for ALNM in Tunisian women with early breast cancer.