EP160/#632 Predictive factors of lymph node involvement in endometrial cancer: a retrospective study of 44 patients. (4th December 2022)

• Record Type: Journal Article
• Authors: Zemni, Ines; Mansouri, Houyem; Boujelbene, Nedia; Achouri, Leila; Yahyaoui, Safia; Chargui, Riadh; Rahal, Khaled
• Is Part Of: International journal of gynecological cancer. Volume 32(2022)Supplement 3
• Page Start: A112
• Page End: A113
• Publication Date: 2022-12-04
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2022-igcs.251
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: To analyze the clinical and histological factors correlated with LN invasion. Methods: We retrospectively included 44 patients treated for EC at the Salah Azaiez Institute over a period of 2 years (2019–2021). Results: The mean age of our patients was 60.20 years (range, 24–81 years).All patients underwent complete resection with combined pelvic and paraaortic lymphadenectomy in 23 cases (52.3%) and isolated pelvic lymphadenectomy in 21 cases (47.7%).Positive LN was assessed in 11 patients (25%).On univariate analysis, LN invasion was significantly correlated to the histological type (p=0.036), tumor grade (p=0.009), depth of myometrial invasion(p=0.018), serous invasion(p=0.003), cervical invasion(p=0.013), lymphovascular space invasion (LVI)(<0.0001) and tumor necrosis (<0.0001).On multivariate analysis, independent factors of LN metastasis were, the presence of LVS (OR=0.312, 95%CI=0.012- 0.533, p=0.041), tumor necrosis (OR=0.431, 95%CI=0.111–0.668, p=0.041) and serous invasion(OR=0.264, 95%CI=0.028–0.690, p=0.034) Conclusions: Since LN metastasis represent an independent prognostic factor for survival, a nomogram based on histological and clinical characteristics could lead to a better detection of patients with high risk of LN metastasis