EP365/#1142 Implementation of novel, alternative and affordable options for ovarian cancer care throughout the entire journey: a KolGo Trg approach. (4th December 2022)

• Record Type: Journal Article
• Authors: Mukhopadhyay, Asima
• Is Part Of: International journal of gynecological cancer. Volume 32(2022)Supplement 3
• Page Start: A202
• Page End: A202
• Publication Date: 2022-12-04
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2022-igcs.454
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: With a predicted 50% rise in incidence and mortality from ovarian cancer by 2040, health-inequality and access to recent paradigm changing treatment options in ovarian cancer care remain a significant challenge in low resource settings. Kolkata Gynecological Oncology Trials and Translational Research Group (KolGo Trg), the first GCIG group from India was formed in 2018 with a mission to address this cancer care gap through academic clinical studies/education/training. Methods: A road map was developed for implementation of a series of sequential studies (OCRN): Optimal surgery/training, targeted/precision surgery in frontline setting ( HIPEC-HR), low- cost predictive biomarkers (academic HRD test- HRDAIC), Nurse-led genetic counselling/awareness ( NUGENA), low-cost treatment options for biochemical recurrence (HOTROC), affordable approaches to parpi therapy ( IPIROC), parpi in arsenic endemic zones (BIODIVARSITY), QOL-studies ( SOCQER-IND), health-economics and willingness to pay studies (HEPTROC), Translational studies (PROVAT), Health policy studies (ROCK- regional ovarian cancer centre, Kolkata), novel statistical designs ( SMART- PARP and RCT- rationalising and reducing the cost of running randomised controlled trials in low resource settings), survivorship/patient-public-involvement ( KOLGO-SURV/SARBOJAYA). Results: We have successfully initiated and implemented all these studies; barriers and challenges are being measured through the REAIM framework for implementation research i.e., feasibility, accessibility, acceptability, cost effectiveness, scalability ( table 1 . www.kolgotrg.org). Some of our studies are being considered for wider global participation through GCIG. Conclusions: This systematic model for addressing novel and affordable indigenous solutions for each step of cancer care could be an exemplar for other cancer types in LMICs.