C−H Activation Based Functionalization of Furfural Derivatives. Issue 43 (25th August 2022)

• Record Type: Journal Article
• Authors: Mori, Alessia; Curpanen, Sebastien; Pezzetta, Cristofer; Perez‐Luna, Alejandro; Poli, Giovanni; Oble, Julie
• Is Part Of: European journal of organic chemistry. Volume 2022:Issue 43(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-25
• Subjects: Biomass -- Catalysis -- C−H Activation -- Furfural -- Transition metal; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202200727
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: Furfural and related compounds are building blocks of industrial interest, obtained from raw biomass. Their use as precursors of basic and fine chemicals has gained increasing attention as a green alternative to petroleum‐derived compounds. Several works have reported the functionalization of furfurals to obtain a wider range of chemicals, opening up new synthetic possibilities and applications, ranging from biofuels to pharmaceuticals. Among these works, processes based on C−H activation are the most attractive ones for their atom economy and the possibility to use non‐activated substrates. This minireview summarizes the reported methods of direct C−H functionalization of furfurals without prior modification of the redox state of the aldehyde function. In particular, the transition metal catalyzed functionalization of each bond of the heteroaromatic nucleus of these molecules is systematically discussed, as well as examples of C−H transformations of the aldehyde function. Abstract : This Review summarizes the reported methods of direct C−H functionalization of furfurals without prior modification of the redox state of the aldehyde function. The aim is to illustrate the different approaches implemented for the functionalization of the C−H positions of the furan ring as well as of the aldehyde functional group.