Adalimumab for the treatment of cardiac sarcoidosis with multiple arrhythmias. (31st August 2022)
- Record Type:
- Journal Article
- Title:
- Adalimumab for the treatment of cardiac sarcoidosis with multiple arrhythmias. (31st August 2022)
- Main Title:
- Adalimumab for the treatment of cardiac sarcoidosis with multiple arrhythmias
- Authors:
- Li, Sitong
Wang, Hui
Liu, Tong
Li, Qifan
Yang, Xiuxiu
Xiong, Ran
Lv, Qiang
Du, Xin
Dong, Jianzeng
Ma, Changsheng - Abstract:
- Abstract: A 45‐year‐old male with cardiac sarcoidosis verified by cardiac biopsy presented with multiple coexisting arrhythmias, including ventricular tachycardia of more than 1000 episodes per 24 h, paroxysmal atrial fibrillation, and third‐degree atrioventricular block. He did not respond to corticosteroids dose of 20–60 mg once daily and mycophenolate mofetil dose of 1 g twice daily for 6 months. Cardiac magnetic resonance (CMR) demonstrated inflammation and late gadolinium enhancement on right ventricular wall and interventricular septum. Positron emission tomography‐computed tomography (PET‐CT) showed multifocal 18 F‐fluorodeoxyglucose uptake in the heart. We replaced mycophenolate mofetil with adalimumab, a tumour necrosis factor‐α inhibitor. After 3 months, his arrhythmias improved significantly, manifesting as premature ventricular contractions of only 500 beats per 24 h and first‐degree atrioventricular block. CMR showed a significant reduction in inflammation and late gadolinium enhancement, and PET‐CT showed a complete resolution of fluorodeoxyglucose uptake.
- Is Part Of:
- ESC heart failure. Volume 9:Number 6(2022)
- Journal:
- ESC heart failure
- Issue:
- Volume 9:Number 6(2022)
- Issue Display:
- Volume 9, Issue 6 (2022)
- Year:
- 2022
- Volume:
- 9
- Issue:
- 6
- Issue Sort Value:
- 2022-0009-0006-0000
- Page Start:
- 4325
- Page End:
- 4329
- Publication Date:
- 2022-08-31
- Subjects:
- Cardiac sarcoidosis -- Ventricular tachycardia -- Adalimumab -- Tumour necrosis factor‐α inhibitor -- Cardiac magnetic resonance -- Positron emission tomography‐computed tomography
Heart failure -- Periodicals
616.129005 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2055-5822 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/ehf2.14133 ↗
- Languages:
- English
- ISSNs:
- 2055-5822
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 24966.xml