EPID-16. SEASONAL INCIDENCE PATTERN COMPARISON BETWEEN PRIMARY AND SECONDARY CENTRAL NERVOUS SYSTEM LYMPHOMAS. (14th November 2022)

• Record Type: Journal Article
• Authors: Yang, Rachel; Demopoulos, Alexis; Li, Jianyi
• Is Part Of: Neuro-oncology. Volume 24(2022)Supplement 7
• Page Start: vii113
• Page End: vii113
• Publication Date: 2022-11-14
• Subjects: Brain Neoplasms -- Periodicals; Brain -- Tumors -- Periodicals; Brain -- Cancer -- Periodicals; Nervous system -- Cancer -- Periodicals; 616.99481
• DOI: 10.1093/neuonc/noac209.426
• Languages: English
• ISSNs: 1522-8517

Abstract

Abstract: OBJECTIVE: To compare primary CNS lymphoma [PCNSL] and secondary CNS lymphoma [SCNSL] incidence by year, month, week, and time between symptom onset, radiographic study, and tissue diagnosis. BACKGROUND: PCNSL is a rare non-Hodgkin's B-cell lymphoma confined to the central nervous system with an increased incidence among immunocompromised patients and immunocompetent patients. 1 Epstein Barr Virus [EBV] infection usually accompanies immunocompromised patients with PCNSL. Whether viral infection is etiologic remains uncertain, especially among the immunocompetent, where EBV is not found. A seasonal pattern was described suggesting an infectious etiology. 2 We sought to add to the literature our experience regarding patterns of disease onset. Design/ METHODS: We retrospectively identified 96 immunocompetent PCNSL patients and 75 SCNSL patients treated here between 2010-20. Complete data was available for 91 PCNSL and 73 SCNSL patients. Variables collected included symptom onset, initial imaging, and tissue collection dates. RESULTS: Weekly incidence was noted in both, with peak of incidence in the 10 th and 40 th week in PCNSL in 9 th, 27 th, and 31 st weeks among SCNSL. Time between symptom onset and first neuroimaging study was significantly different, with PCNSL patients having significantly less time on average. Curiously, the average time between each PCNSL diagnosis was significantly shorter than that for SCNSL diagnosis. CONCLUSION/RELEVANCE: Due to the rarity of the disease, larger studies are needed to further elucidate potential viral etiologies underlying PCNSL.