Adoption of porous nanocomposite fibre scaffold in cartilage injury healing and rehabilitation. (3rd February 2023)

• Record Type: Journal Article
• Authors: Wang, Jucui; Li, Mingzhi
• Is Part Of: International journal of nanotechnology. Volume 19:Number 6/11(2022)
• Page Start: 504
• Page End: 521
• Publication Date: 2023-02-03
• Subjects: nanofibre scaffold -- cartilage defect -- wound healing -- chondrogenic differentiation -- injury rehabilitation; 620.505
• Languages: English
• ISSNs: 1475-7435

Abstract

To evaluate the effect of porous nanofibre scaffold on the healing and repair of cartilage defects in animal models, three different PNFSs were prepared, namely gelatin/polylactic acid scaffold, thermally cross-linked Gel/PLA scaffold, and hyaluronic acid modified Gel/PLA-T scaffold. The characterisation of scaffolds was implemented. Bone marrow stromal cells were taken as the research object, and the detection of cell proliferation and apoptosis was performed to evaluate the biocompatibility of each scaffold after scaffold was co-cultured with cells. A New Zealand rabbit model of cartilage defect was constructed. It showed that the density, mechanical properties, and in vitro degradation rate of HA@Gel/PLA-T scaffolds were remarkably increased relative to Gel/PLA and Gel/PLA-T scaffolds, while the porosity and water absorption rate decreased(P<0.05). It was verified that the prepared HA@Gel/PLA-T composite PNFS can promote the proliferation and chondrogenic differentiation of BMSCs cells, thereby promoting the repair and regeneration of cartilage damaged tissues.