Steroidal alkaloid with unprecedented triheterocyclic architecture. Issue 3 (13th December 2022)

• Record Type: Journal Article
• Authors: Zhou, Zhong-Shun; Zhao, Yun-Li; Hu, Bin-Yuan; Wang, Bei; Liu, Ya-Ping; Zhu, Yan-Yan; He, Ying-Jie; Wang, Zhao-Jie; Dai, Zhi; Zhao, Li-Xing; Luo, Xiao-Dong
• Is Part Of: Chemical communications. Volume 59:Issue 3(2023)
• Page Start: 326
• Page End: 329
• Publication Date: 2022-12-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc06073f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Veratrazine A, a steroidal alkaloid with a unique 6/5/5 triheterocyclic scaffold as the side chain, was isolated from the roots of Veratrum stenophyllum and exhibited moderate and dose-depended anti-inflammatory activities in vitro and in vivo . Abstract : Veratrazine A (1 ), a steroidal alkaloid with a unique 6/5/5 triheterocyclic scaffold as the side chain, was isolated from Veratrum stenophyllum, and its structure was established via spectroscopic analyses and X-ray diffraction. A plausible biosynthetic pathway for 1 is proposed. Bioassy exhibits moderate anti-inflammatory activities in vitro and in vivo .