Molecular and clinical characteristics of carbapenem-resistant Enterobacteriaceae isolates collected at a tertiary hospital in northern China. (25th June 2022)

• Record Type: Journal Article
• Authors: Wang, Hua; Yan, Zhi; Mu, Lan; Gao, Xiang-Yu; Li, Jia-Ying; Hu, Zhi-De; Wang, Jun-Rui; Zheng, Wen-Qi
• Is Part Of: Transactions of the Royal Society of Tropical Medicine and Hygiene. Volume 117:Number 1(2023)
• Page Start: 55
• Page End: 57
• Publication Date: 2022-06-25
• Subjects: antibiotics -- carbapenem-resistant Enterobacteriaceae -- carbapenemase; Tropical medicine -- Periodicals; 616.9883
• DOI: 10.1093/trstmh/trac059
• Languages: English
• ISSNs: 0035-9203

Abstract

Abstract: Background: Carbapenem-resistant Enterobacteriaceae (CRE) represent a severe public health problem. Methods: In a tertiary hospital in northern China, 169 non-duplicated clinical CRE strains were analyzed by species identification, in vitro antibiotics sensitivity test, carbapenemase gene detection and genetic sequence typing. Results: The CRE strains showed high resistance to most clinical antimicrobials. Enterobacter cloacae and Escherichia coli isolates mainly carried blaNDM, and Klebsiella pneumoniae isolates mainly carried blakpc . ST11 was the most common type in Klebsiella pneumoniae, and ST70 was the new emerging sequence type (ST) in Enterobacter cloacae . Conclusions: The CRE strains isolated in northern China showed multidrug-resistant phenotypes, and the new emergence of ST70 Enterobacter cloacae should be closely supervised.