Impairment of skeletal muscle oxygen extraction and cardiac output are matched in precapillary pulmonary hypertension. Issue 3 (31st August 2021)

• Record Type: Journal Article
• Authors: Stubbs, Harrison; Church, Colin; Johnson, Martin; Thomson, Stephen
• Is Part Of: ERJ open research. Volume 7:Issue 3(2021)
• Publication Date: 2021-08-31
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; Respiration; Respiratory organs -- Diseases; Respiratory organs -- Diseases -- Treatment; Respiratory Tract Diseases; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.2005
• DOI: 10.1183/23120541.00449-2021
• Languages: English
• ISSNs: 2312-0541

Abstract

Pulmonary arterial hypertension (PAH) is characterised by pathological pulmonary vascular remodelling and increased resistance leading to right heart failure and death [1]. It is thought that exercise intolerance in PAH arises from an impairment in oxygen transport and delivery, driven by a reduced stroke volume [2]. In precapillary pulmonary hypertension, exercising muscles extract oxygen to a similar level seen in healthy individuals. Exercise limitation is a result of impaired oxygen delivery, which is matched to any impairment in skeletal muscle oxygen extraction. https://bit.ly/3hQUY8m