Higher alveolar deposition of particulate matter in emphysematous lobes of COPD. Issue 3 (31st August 2021)

• Record Type: Journal Article
• Authors: Tung, Nguyen Thanh; Ho, Shu-Chuan; Lu, Yueh-Hsun; Chen, Tzu-Tao; Lee, Kang-Yun; Chen, Kuan-Yuan; Wu, Chih-Da; Chung, Kian Fan; Kuo, Han-Pin; Thao, Huynh Nguyen Xuan; Dung, Hoang Ba; Thuy, Tran Phan Chung; Wu, Sheng-Ming; Kou, Hsiao-Yun; Lee, Yueh-Lun; Chuang, Hsiao-Chi
• Is Part Of: ERJ open research. Volume 7:Issue 3(2021)
• Publication Date: 2021-08-31
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; Respiration; Respiratory organs -- Diseases; Respiratory organs -- Diseases -- Treatment; Respiratory Tract Diseases; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.2005
• DOI: 10.1183/23120541.00324-2021
• Languages: English
• ISSNs: 2312-0541

Abstract

Emphysema can be examined quantitatively on high-resolution computed tomography (HRCT) by measuring the low-attenuation areas of the lung and has been associated with decrease in lung function in patients with COPD [1]. Previous studies have associated levels of air pollution with emphysema severity of the total lung [2, 3]. However, the relationship between inhaled particulate matter (PM) deposition in the lungs and the degree of emphysema at the lung lobar level remains poorly understood. We examined the association of lung lobe-deposited doses of PM2.5 (particles with a 50% cut-off aerodynamic diameter of 2.5 μm) with the extent of emphysema in different lung lobes of COPD subjects. The novelty of this study is that it identified the associations between PM2.5 deposition in the lung and the degree of emphysema in different lung lobes of COPD patients, especially in the right middle lobe and both upper lobes https://bit.ly/3k21ri0