Clinical characteristics of immunoglobulin G4-positive interstitial pneumonia. Issue 3 (31st August 2021)

• Record Type: Journal Article
• Authors: Komatsu, Masamichi; Yamamoto, Hiroshi; Matsui, Shoko; Terasaki, Yasuhiro; Hebisawa, Akira; Iwasawa, Tae; Johkoh, Takeshi; Baba, Tomohisa; Miyamoto, Atsushi; Handa, Tomohiro; Tomii, Keisuke; Waseda, Yuko; Bando, Masashi; Ishii, Haruyuki; Miyazaki, Yasunari; Yoshizawa, Akihiko; Takemura, Tamiko; Kawabata, Yoshinori; Ogura, Takashi
• Is Part Of: ERJ open research. Volume 7:Issue 3(2021)
• Publication Date: 2021-08-31
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; Respiration; Respiratory organs -- Diseases; Respiratory organs -- Diseases -- Treatment; Respiratory Tract Diseases; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.2005
• DOI: 10.1183/23120541.00317-2021
• Languages: English
• ISSNs: 2312-0541

Abstract

Immunoglobulin G4 -related disease is a systemic disease characterised by tumefactive lesions with abundant IgG4 -positive plasma cells and elevated serum IgG4 concentrations [1–4]. We previously assessed IgG4 -related respiratory disease (IgG4 -RRD) with extrathoracic manifestations [5]. IgG4 -RRD develops through the lymphatic routes in the lungs and responds well to corticosteroid therapy with a benign prognosis [5–7]. However, whether interstitial pneumonia (IP) with IgG4 -positive plasma cell infiltration in the lungs without the extrathoracic lesions of IgG4 -related disease could be considered a type of IgG4 -RRD is controversial. This study suggests that IgG4 + IP with abundant IgG4 + cells and elevated serum IgG4 levels could be treated differently from IgG4 -related respiratory disease due to potential differences in disease behaviour and response to corticosteroid therapy https://bit.ly/3dUo2cu