Confocal laser endomicroscopy to guide sampling of a pure ground-glass opacity. Issue 2 (6th April 2021)

• Record Type: Journal Article
• Authors: Viatgé, Thibault; Villeneuve, Thomas; D'Aure, Dominique; Mazières, Julien; Plat, Gavin; Hermant, Christophe; Guibert, Nicolas
• Is Part Of: ERJ open research. Volume 7:Issue 2(2021)
• Publication Date: 2021-04-06
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; Respiration; Respiratory organs -- Diseases; Respiratory organs -- Diseases -- Treatment; Respiratory Tract Diseases; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.2005
• DOI: 10.1183/23120541.00910-2020
• Languages: English
• ISSNs: 2312-0541

Abstract

We read with great interest the article "Needle-based confocal laser endomicroscopy [CLE] for real-time diagnosing and staging of lung cancer" by Wijmans et al. [1], recently published in the European Respiratory Journal, demonstrating the feasibility and safety of realtime lung cancer detection by endosonography-guided CLE. The authors elegantly describe three CLE characteristics for lung cancer: dark, enlarged pleomorphic cells; dark clumps; and directional streaming. The accuracy of CLE for detecting malignancy was 90% in tumours and 89% in metastatic lymph nodes. Confocal laser endomicroscopy imaging of lepidic adenocarcinomas is feasible. This technique should be further evaluated as a realtime guiding tool during virtual electromagnetic navigation bronchoscopy for ground-glass opacities https://bit.ly/3uzTcMU