Analysis of pathological changes in the epithelium in COVID-19 patient airways. Issue 2 (6th April 2021)

• Record Type: Journal Article
• Authors: Yin, Wenguang; Cao, Weitao; Zhou, Guangde; Wang, Lifei; Sun, Jing; Zhu, Airu; Wang, Zhongfang; Zhou, Yumin; Liu, Xiaoqing; Li, Yimin; Zhong, Nanshan; Zhao, Jincun; Liu, Lei; Ran, Pixin
• Is Part Of: ERJ open research. Volume 7:Issue 2(2021)
• Publication Date: 2021-04-06
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; Respiration; Respiratory organs -- Diseases; Respiratory organs -- Diseases -- Treatment; Respiratory Tract Diseases; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.2005
• DOI: 10.1183/23120541.00690-2020
• Languages: English
• ISSNs: 2312-0541

Abstract

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 70 million infections and approximately 1.6 million deaths worldwide [1]. However, the pathological changes in coronavirus disease 2019 (COVID-19) airways remain unclear due to limited accessibility of autopsy or biopsy. Severe COVID-19 patient airways plugged by MUC5AC-containing mucus exhibit hyperplasia of goblet cells, and hypoplasia of multiciliated cells and club cells, as well as significantly reduced CC16 and MUC5B levels, and increased IL-13 levels https://bit.ly/2M2NcdO