Phenotypic characterisation of early COPD: a prospective case–control study. Issue 4 (5th October 2020)

• Record Type: Journal Article
• Authors: Cosío, Borja G.; Pascual-Guardia, Sergi; Borras-Santos, Alicia; Peces-Barba, Germán; Santos, Salud; Vigil, Laura; Soler-Cataluña, Juan José; Martínez-González, Cristina; Casanova, Ciro; Marcos, Pedro J.; Alvarez, Carlos J.; López-Campos, José Luis; Gea, Joaquim; Garcia-Aymerich, Judith; Molina, Jesús; Román, Miguel; Moises, Jorge; Szabo, Viktoria; Reagan, Elizabeth A.; San José Estépar, Raúl; Washko, George; Agustí, Alvar; Faner, Rosa
• Other Names: author non-byline.; Cosio Borja G. author non-byline.; Cordova Diaz Rocío author non-byline.; Pan Naranjo María Magdalena author non-byline.; Sancho Joan Palmer author non-byline.; Rodríguez Miguel Román author non-byline.; Agustí Alvar author non-byline.; Canet Rosa Faner author non-byline.; Barberà Joan Albert author non-byline.; Torrent Josep Roca author non-byline.; Torralba Garcia Yolanda author non-byline.; Lafuente Jorge Moises author non-byline.; Pedro Pijoan Anna Maria author non-byline.; Docón Amparo Hervas author non-byline.; Herranz Carmen author non-byline.; Sanchez Ruano Núria author non-byline.; Gea Joaquim author non-byline.; ChiaradíaRodríguez Diego A author non-byline.; Rodó-Pin Anna author non-byline.; Martín-Ontiyuelo Clara author non-byline.; Admetlló Mireia author non-byline.; Castro Concepción Ballano author non-byline.; Gutiérrez Martín Laura author non-byline.; Aoiz Linares JoséIgnacio author non-byline.; Pascual-Guardia Sergi author non-byline.; Mourelo Cereijo Marta author non-byline.; Peces-Barba Romero Germán author non-byline.; Fernández Arias José author non-byline.; Rivera Carolina Gotera author non-byline.; Bernal Manuel Martin author non-byline.; Madueño Guillermo Gallardo author non-byline.; Alcázar Peral Andrés author non-byline.; Miras Carmelo Palacios author non-byline.; Pinedo Moraleda Maria Teresa author non-byline.; Torres Labandeira Maria Belén author non-byline.; Rodríguez Mercedes Colomo author non-byline.; Rodríguez Gallego María Concepción author non-byline.; Lobon Agundez Carmen author non-byline.; Nácher Conches Mónica author non-byline.; Mansilla María José author non-byline.; Martín Rosario Serrano author non-byline.; Martínez Carlos J. Álvarez author non-byline.; Bernáldez Marta Padilla author non-byline.; París Jesús Molina author non-byline.; Giménez Laura Vigil author non-byline.; Molas Eduard Monsó author non-byline.; Gort Laia Seto author non-byline.; Baré Mañas Montserrat author non-byline.; Fabra Noguera Anna Maria author non-byline.; López Campos JoséLuís author non-byline.; Acuña Carmen Calero author non-byline.; Hernández Laura Carrasco author non-byline.; Santos Perez Salud author non-byline.; Navarro Montserrat author non-byline.; Serra Elisabeth author non-byline.; Keysers Ferran Ferrer author non-byline.; Batallé Damaris author non-byline.; Dolores Peleato Catalan M author non-byline.; Dorca Albert author non-byline.; Burgos Javier author non-byline.; José Juan author non-byline.; Noelia González García Soler-Cataluña author non-byline.; Sánchez Lourdes Sánchez author non-byline.; González Cristina Martínez author non-byline.; Fernández Amador Prieto author non-byline.; González Susana Martínez author non-byline.; Casanova Macario Ciro author non-byline.; Mayato Delia author non-byline.; Marcos Rodriguez Pedro J author non-byline.; Domínguez Juncal Luis author non-byline.; Timiraos Carrasco Rosario author non-byline.; Garcia Palenzuela Rosa author non-byline.;
• Is Part Of: ERJ open research. Volume 6:Issue 4(2020)
• Publication Date: 2020-10-05
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; Respiration; Respiratory organs -- Diseases; Respiratory organs -- Diseases -- Treatment; Respiratory Tract Diseases; Electronic journals; Fulltext; Internet Resources; Periodicals; Periodical; 616.2005
• DOI: 10.1183/23120541.00047-2020
• Languages: English
• ISSNs: 2312-0541

Abstract

The phenotypic characteristics of chronic obstructive pulmonary disease (COPD) in individuals younger than 50 years of age (early COPD) are not well defined. This prospective, multicentre, case–control study sought to describe these characteristics and compare them with those of smokers (≥10 pack-years) of similar age with normal spirometry (controls). We studied 92 cases (post-bronchodilator forced expiratory volume in 1 s (FEV1 )/forced vital capacity (FVC) <0.7) and 197 controls. Results were contrasted with participants with similar inclusion criteria recruited into the ECLIPSE and COPDGene cohorts. Cases had moderate airflow limitation (FEV1 71.3±20.8%) but were often symptomatic, used healthcare resources frequently, had air trapping (residual volume 150.6±55.5% ref.), had reduced diffusing capacity (84.2±20.7% ref.) and had frequent evidence of computed tomography (CT) emphysema (61%). Of note, less than half of cases (46%) had been previously diagnosed with COPD. Interestingly, they also often reported a family history of respiratory diseases and had been hospitalised because of respiratory problems before the age of 5 years more frequently than controls (12% versus 3%, p=0.009). By and large, these observations were reproduced when available in the ECLIPSE and COPDGene cohorts. These results show that early COPD is associated with substantial health impact and significant structural and functional abnormalities, albeit it is often not diagnosed (hence, treated). The fact that a sizeable proportion of patients with early COPD report a family history of respiratory diseases and/or early-life events (including hospitalisations before the age of 5 years) renders further support to the possibility of early-life origin of COPD. Early COPD is associated with substantial health impact, and structural and functional abnormalities, albeit it is often not diagnosed and hence, not treated. It is frequently associated with family history of respiratory diseases and early-life events. https://bit.ly/2ZtoRkp