Gonadotropin-Dependent Precocious Puberty: Neoplastic Causes and Endocrine Considerations. (27th January 2011)

• Record Type: Journal Article
• Authors: Stephen Stephen, Matthew D. Matthew D.; Zage Zage, Peter E. Peter E.; Waguespack Waguespack, Steven G. Steven G.
• Other Names: New New Maria Maria Academic Editor.
• Is Part Of: International journal of pediatric endocrinology. Volume 2011(2011)
• Publication Date: 2011-01-27
• Subjects: Pediatric endocrinology -- Periodicals; Endocrine glands -- Diseases -- Periodicals; 618.924
• DOI: 10.1155/2011/184502
• Languages: English
• ISSNs: 1687-9856

Abstract

Abstract : Premature activation of the hypothalamic-pituitary-gonadal (HPG) axis manifests as gonadotropin-dependent precocious puberty. The mechanisms behind HPG activation are complex and a clear etiology for early activation is often not elucidated. Though collectively uncommon, the neoplastic and developmental causes of gonadotropin-dependent precocious puberty are very important to consider, as a delay in diagnosis may lead to adverse patient outcomes. The intent of the current paper is to review the neoplastic and developmental causes of gonadotropin-dependent precocious puberty. We discuss the common CNS lesions and human chorionic gonadotropin-secreting tumors that cause sexual precocity, review the relationship between therapeutic radiation and gonadotropin-dependent precocious puberty, and finally, provide an overview of the therapies available for height preservation in this unique patient population.