LncRNA LOXL1-AS1 expression in cancer prognosis: A meta-analysis. Issue 52 (30th December 2022)

• Record Type: Journal Article
• Authors: Wang, Xuhua; Chen, Zhaoyuan; Zhou, Huaqiang; Liu, Wuyang; Luo, Jiaquan
• Is Part Of: Medicine. Volume 101:Issue 52(2022)
• Page Start: e32436
• Publication Date: 2022-12-30
• Subjects: cancer -- LncRNA LOXL1-AS1 -- meta-analysis -- prognosis; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000032436
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Background: Several studies showed that LncRNA LOXL1 antisense RNA 1 (LOXL1-AS1) is overexpressed in a variety of cancers and plays a role as an oncogene in cancer. The present meta-analysis aims to elucidate the relationship between LOXL1-AS1 expression and prognosis and clinicopathological features among cancer patients. Methods: PubMed, Web of Science, Cochrane Library, and EMBASE database were comprehensively and systematically searched. Pooled odds ratios (ORs) and hazard ratios with a 95% confidence interval (CI) were employed to assess the relationship between LOXL1-AS1 expression and clinical outcomes and clinicopathological features in cancer patients. Results: The present study finally enrolled 8 studies which included 657 cancer patients. The combined results indicated that the overexpression of LOXL1-AS1 was significantly associated with shorter overall survival (pooled hazard ratio = 1.99, 95% CI 1.49–2.65, P < .00001). Meanwhile, regarding clinicopathology of cancer patients, the upregulation of LOXL1-AS1 expression was closely related to lymph node metastasis (yes vs no OR = 4.01, 95% CI: 2.02–7.96, P < .0001) and distant metastasis (yes vs no OR = 3.04, 95% CI: 1.82–5.06, P < .0001), respectively. Conclusion: High expression of LOXL1-AS1 in some cancers predicts shorter overall survival, distant metastasis, and lymph node metastasis. LOXL1-AS1 shows great promise as a prognostic biomarker in cancer patients.