A review of autoimmunity and immune profiles in patients with primary ovarian insufficiency. Issue 51 (23rd December 2022)

• Record Type: Journal Article
• Authors: Chen, Junyu; Wu, Shan; Wang, Mengqi; Zhang, Haoxian; Cui, Manhua
• Is Part Of: Medicine. Volume 101:Issue 51(2022)
• Page Start: e32500
• Publication Date: 2022-12-23
• Subjects: autoimmunity -- cytokines -- oophoritis -- ovarian reserve -- primary ovarian insufficiency; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000032500
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Primary ovarian insufficiency (POI) is a complicated clinical syndrome characterized by progressive deterioration of ovarian function. Autoimmunity is one of the main pathogenic factors affecting approximately 10% to 55% of POI cases. This review mainly focuses on the role of autoimmunity in the pathophysiology of POI and the potential therapies for autoimmunity-related POI. This review concluded that various markers of ovarian reserve, principally anti-Müllerian hormone, could be negatively affected by autoimmune diseases. The presence of lymphocytic oophoritis, anti-ovarian autoantibodies, and concurrent autoimmune diseases, are the main characteristics of autoimmune POI. T lymphocytes play the most important role in the immune pathogenesis of POI, followed by disorders of other immune cells and the imbalance between pro-inflammatory and anti-inflammatory cytokines. A comprehensive understanding of immune characteristics of patients with autoimmune POI and the underlying mechanisms is essential for novel approaches of treatment and intervention for autoimmune POI.