The ProtekDuo in ECMO configuration for ARDS secondary to COVID-19: A systematic review. Issue 2 (February 2023)

• Record Type: Journal Article
• Authors: Maybauer, Marc O; Capoccia, Massimo; Maybauer, Dirk M; Lorusso, Roberto; Swol, Justyna; Brewer, Joseph M
• Is Part Of: International journal of artificial organs. Volume 46:Issue 2(2023)
• Page Start: 93
• Page End: 98
• Publication Date: 2023-02
• Subjects: ECLS -- extracorporeal life support -- extracorporeal membrane oxygenation -- percutaneous -- RVAD -- right ventricular assist device -- ProtekDuo; Artificial organs -- Periodicals; 617.956
• DOI: 10.1177/03913988221142904
• Languages: English
• ISSNs: 0391-3988

Abstract

Objective: Assessment of the results of the ProtekDuo cannula applied for dedicated right ventricular support with oxygenator in ARDS secondary to COVID-19. Methods: Systematic literature search in NHS library, Medline (Pubmed) and EMBASE using appropriate keywords as well as PICOS and PRISMA approach. Results: Out of 285 publications found, 5 publications met the search criteria and were included in this review. A total of 194 patients with ARDS secondary to COVID-19 underwent ProtekDuo placement to establish a combination of respiratory [veno-venous extracorporeal membrane oxygenation (V-V ECMO)] and right ventricular support. Patients treated using the ProtekDuo cannula had survival rates between 59% and 89% throughout the five studies, and a significant survival benefit when compared to an invasive ventilation group or compared to dual site V-V ECMO or other double lumen ECMO cannulas. One study focused on extubation and discontinuation of ventilator support, which could be achieved in 100% of ProtekDuo patients. An association for reduced incidence of acute kidney injury (AKI) and use of continuous renal replacement therapy (CRRT) could be shown when the ProtekDuo was used. Conclusion: Only limited literature is available for the ProtekDuo in V-P ECMO configuration in the setting of COVID-19 ARDS and should be interpreted with caution. Data on the ProtekDuo is suggestive for lower rates of mortality, AKI and CRRT as compared to other respiratory support modalities.