Efficacy of hemoperfusion with Seraph-100 in series with single pass albumin dialysis in acute hepatitis B infection: A case report. Issue 2 (February 2023)

• Record Type: Journal Article
• Authors: Piscitani, Luca; Leone, Silvia; Di Biase, Jessica; Salvati, Lia; Sirolli, Vittorio; Tunno, Marilena; Bonomini, Mario
• Is Part Of: International journal of artificial organs. Volume 46:Issue 2(2023)
• Page Start: 81
• Page End: 84
• Publication Date: 2023-02
• Subjects: Acute hepatitis B -- hemoperfusion -- albumin dialysis -- liver failure -- Seraph 100 filter; Artificial organs -- Periodicals; 617.956
• DOI: 10.1177/03913988221143142
• Languages: English
• ISSNs: 0391-3988

Abstract

Acute and acute-on-chronic liver failure is a cause of death in patients suffering from viral hepatitis, and many cases need liver transplantation. Infection from hepatitis B virus may range from asymptomatic to severe acute and fulminant hepatitis. In this setting, treatment is mainly supportive as there is no consensus on antiviral therapy based on non-nucleoside reverse transcriptase inhibitors. Single-pass albumin dialysis is a liver-support technique for patients suffering from liver failure, that has shown effectiveness in the removal of both water-soluble and albumin-bound toxins, which accumulate due to impairment of the liver's cleansing function. We report here the case of a 62-year-old male who presented with a severe acute hepatitis B infection, liver failure, and marked hyperbilirubinemia. Treatment with single-pass albumin dialysis combined with a hemoperfusion device was successful in improving clinical, physiological, and laboratory parameters.