Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG). (1st December 2021)

• Record Type: Journal Article
• Authors: Olsen, E. A.; Harries, M.; Tosti, A.; Bergfeld, W.; Blume‐Peytavi, U.; Callender, V.; Chasapi, V.; Correia, O.; Cotsarelis, G.; Dhurat, R.; Dlova, N.; Doche, I.; Enechukwu, N.; Grimalt, R.; Itami, S.; Hordinsky, M.; Khobzei, K.; Lee, W. ‐S.; Malakar, S.; Messenger, A.; McMichael, A.; Mirmirani, P.; Ovcharenko, Y.; Papanikou, S.; Pinto, G. M.; Piraccini, B. M.; Pirmez, R.; Reygagne, P.; Roberts, J.; Rudnicka, L.; Saceda‐Corralo, D.; Shapiro, J.; Silyuk, T.; Sinclair, R.; Soares, R. O.; Souissi, A.; Vogt, A.; Washenik, K.; Zlotogorski, A.; Canfield, D.; Vano‐Galvan, S.;
• Is Part Of: British journal of dermatology. Volume 185:Number 6(2021)
• Page Start: 1221
• Page End: 1231
• Publication Date: 2021-12-01
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.20567
• Languages: English
• ISSNs: 0007-0963

Abstract

Summary: Background: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives: To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods: A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results: Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions: These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.