Computed tomographic airway morphology after targeted lung denervation treatment in COPD. (January 2023)

• Record Type: Journal Article
• Authors: Hartman, Jorine E.; Herth, Felix J.F.; Shah, Pallav; Pison, Christophe; Valipour, Arschang; Slebos, Dirk-Jan; Valipour, Arschang; Abele, Christine; Firlinger, Irene; Kothakuzhakal, Kiran; Duller, Marina; Lamprecht, Bernd; Kropfmueller, Roland; Holzmann, Kornelia; Rathmeier, Sandra; Hubner, Ralf; Erdmann, Leonore; Temmesfeld-Wollbrück, Bettina; Ruwwe Glösenkamp, Christoph; Gesierich, Wolfgang; Reichenberger, Frank; Niehaus, Christa; Herth, Felix; Eberhardt, Ralf; Gompelmann, Daniela; Rump, Brigitte; Darwiche, Kaid; Eisenmann, Stephan; Kaiser, Ulrike; Schwarz, Birte; Sampel, Ulrike; Schumann, Christian; Kaiser, Robert; Schumann-Stoiber, Kathryn; Skowasch, Dirk; Ring, Sabine; Pison, Christophe; Briault, Amandine; Arbib, Francois; Jondot, Marie; Perez, Thierry; Fournier, Clement; Matran, Regis; Catto, Michele; Bautin, Nathalie; De Broucker, Virginie; Willemin, Marie; Prevotat, Anne; Wemeau, Ludivine; Gicquello, Alice; Foulon, Morgane; Camara, Hasna; Deslee, Gaetan; Vallerand, Herve; Dury, Sandra; Gras, Delphine; Bonnaire-Verdier, Margaux; Kessler, Romain; Hirschi, Sandrine; Porzio, Michele; Degot, Tristan; Canuet, Mathieu; Schuller, Armelle; Stauder, Julien; Azouaou, Sahra Ali; Marceau, Armelle; Mal, Hervé; Costa, Yolande; Shah, Pallav L.; Garner, Justin; Srikanthan, Karthi; Caneja, Cielito; Thornton, John; Slebos, Dirk-Jan; Hacken, Nick Ten; Hartman, Jorine; Klooster, Karin; Augustijn, Sonja; Bonta, Peter; Annema, Jouke; van de Pol, Marianne; Goorsenberg, Annika;
• Is Part Of: Respiratory medicine. Volume 206(2023)
• Publication Date: 2023-01
• Subjects: Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2022.107059
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: This post-hoc analysis of the AIRFLOW-2 trial investigated the changes in airway CT-parameters after targeted lung denervation (TLD) and whether these changes are associated with treatment response. In the treatment group (n = 32), an improvement in air trapping was significantly associated with an improvement in residual volume (RV). Furthermore, improvements in Pi10 and airway lumen were significantly associated with an improvement in both RV and FEV1 . Our results could suggest that when improving airway characteristics like decreasing airway wall thickness and increasing the airway lumen, this leads to less air trapping and an improvement in clinical outcomes. Highlights: So far changes in airway CT parameters were not investigated after targeted lung denervation (TLD). No significant changes in CT parameters were found after TLD treatment compared to a control group. An improvement in air trapping was significantly associated with an improvement in residual volume. Improvements in Pi10 and airway lumen were significantly associated with improvements in RV and FEV1 . Improving airway characteristics could lead to less air trapping and improvements in clinical outcomes.